Developed as part of the U.S. Cluster Mapping Project, the Minneapolis-St. Paul Regional Cluster Initiative is a study on how the Minneapolis-St. Paul region has benefited from applying a cluster approach as a conceptual framework for diagnosing the regional economy and as a platform for joint action to address the challenges identified. This is a companion piece to Mobilizing Oregon Clusters, the Precision Manufacturing Regional Alliance, and New Carolina, marking the completion of the set of U.S. Cluster Mapping Policy and Impact Studies.